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The 20 mg dose showed only marginal efficacy gains over 15 mg (roughly 0.1% additional HbA1c reduction) but had significantly higher rates of nausea, vomiting, and treatment discontinuation

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Importantly, blood clots were not identified as a significant adverse event in these comprehensive studies, and thrombotic events did not occur at rates higher than expected in the study populations, as confirmed in the European Medicines Agency's European Public Assessment Report (EPAR)